Butyrolactone 3
| Code | Size | Price |
|---|
| AG-CR1-3522-M002 | 2 mg | £90.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
(2R,3S)-rel-Tetrahydro-4-methylene-5-oxo-2-propyl-3-furancarboxylic acid; MB-3
Appearance:
White to off-white solid.
CAS:
778649-18-6
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07
Hazards:
H302, H319
InChi:
InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m0/s1
InChiKey:
SRQUTZJZABSZRQ-NKWVEPMBSA-N
Long Description:
Chemical. CAS: 778649-18-6. Formula: C9H12O4. MW: 184.2. Synthetic Specific histone acetyltransferase Gcn5 inhibitor. Anticancer compound. Pre-mRNA splicing inhibitor. Blocks splicing before the first catalytic steps. Potential anti-inflammatory compound.
MDL:
MFCD08702690
Molecular Formula:
C9H12O4
Molecular Weight:
184.2
Package Type:
Vial
Precautions:
P264, P270, P280, P301, P312
Product Description:
Specific histone acetyltransferase Gcn5 inhibitor [1, 2]. Anticancer compound [2, 4]. Pre-mRNA splicing inhibitor. Blocks splicing before the first catalytic steps [3]. Potential anti-inflammatory compound.
Purity:
>95% (NMR)
Signal Word:
Warning
SMILES:
CCC[C@@H]1OC(=O)C(=C)[C@H]1C(O)=O
Solubility Chemicals:
Soluble in DMSO or methanol.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5: M. Biel, et al.; Angew. Chem. Int. Ed. Engl. 43, 3974 (2004) | Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties: A. Mai, et al.; J. Med. Chem. 49, 6897 (2006) | Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation: A.N. Kuhn, et al.; RNA 15, 153 (2009) | GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia: T. Holmlund, et al.; Leukemia 27, 578 (2013)