Hemagglutinin Monoclonal Antibody

Product Code: PSI-PM-4009

Supplier: ProSci

Code	Size	Price

PSI-PM-4009-0.02mg

0.02mg

£150.00

Quantity:

PSI-PM-4009-0.1mg

0.1mg

£515.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Mouse

Antibody Clonality: Monoclonal

Antibody Clone: 7B9B2

Regulatory Status: RUO

Applications:

Enzyme-Linked Immunosorbent Assay (ELISA)
Western Blot (WB)

Images

1 / 1

Western blot analysis of (A) 5 ng and (B) 25 ng of recombinant HA1 with Hemagglutinin antibody at 1 μg/mL.

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Documents

Further Information

Additional Names:

Hemagglutinin Antibody [7B9B2] :

Application Note:

Hemagglutinin antibody can be used for the detection of the Hemagglutinin protein from the H5N1 strain of avian influenza A in ELISA. It will detect 10 ng of free peptide at 1 μg/mL. Other applications are pending.

Background:

Hemagglutinin Monoclonal Antibody: Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. The more recent virulent strain of H5N1 is now seen in Africa and Europe, as well as in southeast Asia. There is some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability. While efforts were made to use relatively conserved regions of the viral sequence as the antigen, the influenza virus genome has drifted somewhat from what was first reported. However, this antibody was able to recognize peptides derrived from viruses from Indonesian human patients infected in 2007.

Background References:

Thompson WW, Shay DK, Weintraub, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003; 289:179-186.
Alexander DJ. A review of avian influenza. Proceedings of the European Society for Veterinary Virology (ESVV) Symposium on Influenza Viruses of Wild and Domestic Animals. Vet. Microbiol. 2000; 74:3-13.
Shortridge KF, Zhou NN, Guan Y, et al. Characterization of avian H5N1 influenza viruses from poultry in Hong Kong. Virol. 1998; 252:331-342.
Buxton Bridges C, Katz JM, Seto WH, et al. Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong. J. Inf. Dis. 2000; 181:344-8.

Buffer:

Hemagglutinin Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration:

1 mg/mL

Conjugate:

Unconjugated

DISCLAIMER:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Immunogen:

A peptide corresponding to 13 amino acids in the middle of the Hemagglutinin protein.

NCBI Official Name:

hemagglutinin

NCBI Organism:

Influenza A virus (A/chicken/Jilin/9/2004(H5N1))

Physical State:

Liquid

Protein Accession #:

AAT76166

Protein GI Number:

50365729

Purification:

Hemagglutinin Monoclonal Antibody is Protein A purified.

Research Area:

Infectious Disease

Swissprot #:

Q692M2

User NOte:

Optimal dilutions for each application to be determined by the researcher.

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