ERGIC53 Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-PM-7213-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-PM-7213-0.1mg | 0.1mg | £515.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 7
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ERGIC53 Monoclonal Antibody: Lectin mannose-binding 1, LMAN1, endoplasmic reticulum-golgi intermediate compartment protein 53, ERGIC-53, F5F8D, FMFD1, MCFD1, MR60, gp58
Application Note:
ERGIC53 antibody can be used for detection of ERGIC53 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL.
Background:
ERGIC53 Monoclonal Antibody: ERGIC53, also known as lectin mannose-binding 1 (LMAN1) protein is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
Background References:
- Schindler R, Itin C, Zerial M, et al. ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif. Eur. J. Cell Biol. 1993; 61:1-9.
- ERGIC-53 is a functional mannose-selective and calcium-dependent human homologue of leguminous lectins. Mol. Biol Cell 1996; 7:483-93
- Zhang YC, Zhou Y, Yang CZ, et al. A review of ERGIC-53: its structure, functions, regulation and relations with diseases. Histol. Histopathol. 2009; 24:1193-204.
Buffer:
ERGIC53 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Mouse monoclonal ERGIC53 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ERGIC53.
NCBI Gene ID #:
3998
NCBI Official Name:
lectin, mannose-binding, 1
NCBI Official Symbol:
LMAN1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 56 kDa
Protein Accession #:
NP_005561
Protein GI Number:
5031873
Purification:
ERGIC53 Monoclonal Antibody is Protein A purified.
Research Area:
Homeostasis
SPECIFICITY:
At least two isoforms of ERGIC53 are known to exist.
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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