CCR5 Antibody
| Code | Size | Price |
|---|
| PSI-1112-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-1112-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CCR5 Antibody: CKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5, C-C chemokine receptor type 5, CHEMR13, C-C CKR-5
Application Note:
CCR5 antibody can be used for Western blot at 1 μg/mL. CCR5 antibody can also detect CCR5 by immunohistochemistry at 2.5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CCR5 Antibody: Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
Background References:
- Dimitrov, DS. Cell 1997; 91:721-30
- Littman, DR. Cell 1998; 93:677-80
- Deng, H, et al. Nature 1996; 381:661-6
- Dragic, T, et al. Nature 1996; 381:667-73
Buffer:
CCR5 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CCR5 antibody was raised against a 15 amino acid peptide near the amino terminus of human CCR5.
The immunogen is located within the first 50 amino acids of CCR5.
The immunogen is located within the first 50 amino acids of CCR5.
NCBI Gene ID #:
1234
NCBI Official Name:
chemokine (C-C motif) receptor 5
NCBI Official Symbol:
CCR5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 39 kDa
Observed: 40 kDa
Observed: 40 kDa
Protein Accession #:
AAB57793
Protein GI Number:
2104520
Purification:
CCR5 Antibody is affinity chromatography purified via peptide column.
Research Area:
Chemokines & Cytokines,Cancer,Infectious Disease
Swissprot #:
P51681
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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