IL-1RAcP Antibody
| Code | Size | Price |
|---|
| PSI-2129-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-2129-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
IL-1RAcP Antibody: IL1R3, C3orf13, IL-1RAcP, IL1R3, Interleukin-1 receptor accessory protein, Interleukin-1 receptor 3, IL-1 receptor accessory protein
Application Note:
IL-1RAcP antibody can be used for detection of IL-1RAcP by Western blot at 1 μg/mL. Antibody can also be used for Immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
IL-1RAcP Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-κB inducing kinae (NIK) and of NF-κB, recruits to the IL-1R complex through IL-1RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.
Background References:
- Greenfeder SA, Nunes P, Kwee L, et al. Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J. Biol. Chem. 1995; 270:13757-65.
- Huang J, Gao X, Li S, et al. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc. Natl. Acad. Sci. USA 1997; 94:12829-32.
- Wesche H, Korherr C, Kracht M, et al. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J. Biol. Chem. 1997; 272:7727-31.
- Hofmeister R, Wiegmann K, Korherr C, et al. Activation of acid sphingomyelinase by interleukin-1 (IL-1) requires the IL-1 receptor accessory protein. J. Biol. Chem. 1997; 272:27730-6.
Buffer:
IL-1RAcP Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%), Mouse: (100%)
Immunogen:
IL-1RAcP antibody was raised against a 16 amino acid peptide near the carboxy terminus of human IL-1RAcP.
The immunogen is located within the last 50 amino acids of IL-1RAcP.
The immunogen is located within the last 50 amino acids of IL-1RAcP.
NCBI Gene ID #:
3556
NCBI Official Name:
interleukin 1 receptor accessory protein
NCBI Official Symbol:
IL1RAP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 63 kDa
Observed: 66 kDa
Observed: 66 kDa
Protein Accession #:
NP_001161401
Protein GI Number:
2599126
Purification:
IL-1RAcP Antibody is affinity chromatography purified via peptide column.
Research Area:
Chemokines & Cytokines
SPECIFICITY:
This polyclonal antibody has no cross activity to other members in the IL-1 receptor family.
Swissprot #:
Q9NPH3
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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