APRIL Antibody

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ProSci
Product Code: PSI-2415
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-2415-0.02mg0.02mg£150.00
Quantity:
PSI-2415-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of APRIL expression in Jurkat cells with APRIL antibody at 1 μg/mL (A), 2 μg/mL (B), and 4 μg/mL (C).
2 / 2
Immunohistochemistry of APRIL in human prostate tissue with APRIL antibody at 10 μg/mL.
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Western blot analysis of APRIL expression in Jurkat cells with APRIL antibody at 1 μg/mL (A), 2 μg/mL (B), and 4 μg/mL (C).
Immunohistochemistry of APRIL in human prostate tissue with APRIL antibody at 10 μg/mL.

Documents

Further Information

Additional Names:
APRIL Antibody: APRIL, CD256, TALL2, ZTNF2, TALL-2, TRDL-1, UNQ383/PRO715, APRIL, Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand
Application Note:
APRIL antibody can be used for detection of APRIL by Western blot at 1 - 4 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
APRIL Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1α (for TNF related death ligand 1α) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.
Background References:
  • Hahne M, Kataoka T, Schroter M, et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J. Exp. Med. 1998; 188:1185-90.
  • Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukoc. Biol. 1999; 65:680-3.
  • Kelly K, Manos E, Jensen G, et al. APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. Cancer Res. 2000; 60:1021-7.
  • Yu G, Boone T, Delaney J, et al. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat. Immunol. 2000; 1:252-6.
Buffer:
APRIL Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
APRIL antibody was raised against a synthetic peptide corresponding to amino acids within a extracellular domain of human APRIL.

The immunogen is located within amino acids 180 - 230 of APRIL.
NCBI Gene ID #:
8741
NCBI Official Name:
tumor necrosis factor (ligand) superfamily, member 13
NCBI Official Symbol:
TNFSF13
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 27 kDa

Observed: 27 kDa
Protein Accession #:
NP_003799
Protein GI Number:
4507599
Purification:
APRIL Antibody is affinity chromatography purified via peptide column.
Research Area:
Chemokines & Cytokines,Cancer
Swissprot #:
O75888
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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