IL-21 Receptor Antibody
| Code | Size | Price |
|---|
| PSI-2469-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-2469-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
IL-21 Receptor Antibody: NILR, CD360, NILR, UNQ3121/PRO10273, Interleukin-21 receptor, Novel interleukin receptor, IL-21 receptor
Application Note:
IL-21 receptor antibody can be used for detection of IL-21 receptor by Western blot at 1-2 μg/mL. An approximately 60 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in human and rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in human and rat samples. All other applications and species not yet tested.
Background:
IL-21 Receptor Antibody: A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. Both IL-21R and the gammac are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Background References:
- Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408(6808):57-63.
- Ozaki K, Kikly K, Michalovich D, et al.? Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain. Proc Natl Acad Sci USA. 2000;97(21):11439-44.
- Asao H, Okuyama C, Kumaki S, et al. the common γ-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 2001;167(1):1-5.
- Vosshenrich CA, Di Santo JP. Cytokines: IL-21 joins the γ(c)-dependent network.Curr Biol. 2001;11(5):R175-7.
Buffer:
IL-21 Receptor Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IL-21 receptor antibody was raised against a synthetic peptide corresponding to amino acids 97 to 111 of human IL-21 receptor precursor.
The immunogen is located within amino acids 80 - 130 of IL-21 Receptor.
The immunogen is located within amino acids 80 - 130 of IL-21 Receptor.
NCBI Gene ID #:
50615
NCBI Official Name:
interleukin 21 receptor
NCBI Official Symbol:
IL21R
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 60 kDa
Observed: 62 kDa????????
Observed: 62 kDa????????
Protein Accession #:
NP_068570
Protein GI Number:
11141869
Purification:
IL-21 Receptor Antibody is affinity chromatography purified via peptide column.
Research Area:
Chemokines & Cytokines
Swissprot #:
Q9HBE5
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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