TTC5 Antibody

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ProSci
Product Code: PSI-3053
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-3053-0.02mg0.02mg£150.00
Quantity:
PSI-3053-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of TTC5 in RAW264.7 cell lysate with TTC5 antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.
2 / 3
Immunohistochemistry of TTC5 in mouse brain tissue with TTC5 antibody at 10 μg/mL.
3 / 3
Immunofluorescence of TTC5 in Mouse Brain cells with TTC5 antibody at 20 μg/mL.
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Western blot analysis of TTC5 in RAW264.7 cell lysate with TTC5 antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.
Immunohistochemistry of TTC5 in mouse brain tissue with TTC5 antibody at 10 μg/mL.
Immunofluorescence of TTC5 in Mouse Brain cells with TTC5 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
TTC5 Antibody: Strap, Tetratricopeptide repeat protein 5, Stress-responsive activator of p300, TPR repeat protein 5
Application Note:
TTC5 antibody can be used for the detection of TTC5 by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
TTC5 Antibody: Tetratricopeptide repeat protein 5 (TTC5) is a member of a diverse group of functionally distinct proteins that are characterized by containing one or more tetratricopeptide repeats. Each motif consists of two anti-parallel a-helices such that tandem arrays of TPR motifs generate a right-handed helical structure with an amphipathic channel that may serve to accommodate the complementary region of a target protein. While the exact function of TTC5 remains unclear, it is thought that the TPR motifs serve to mediate protein-protein interactions such as those seen with protein chaperones HSP70 and HSP90 and some proteins involved in cell stress response signaling pathways such as protein phosphatase 5, suggesting that TTC5 may also function via protein-protein interactions mediated by its TPR motifs.
Background References:
  • Blatch GL and Lassle M. The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. BioEssays 1999; 21:932-9
  • Song Y and Masison DC. Independent regulation of Hsp70 and Hsp90 chaperones by Hsp70/Hsp90-organizing protein Sti1 (Hop1). J. Biol. Chem. 2005; 280:34178-85.
  • Yang J, Roe SM, Cliff MJ, et al. Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. EMBO J. 2005; 24:1-10.
Buffer:
TTC5 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (93%)
Immunogen:
TTC5 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human TTC5.

The immunogen is located within the last 50 amino acids of TTC5.
NCBI Gene ID #:
91875
NCBI Official Name:
tetratricopeptide repeat domain 5
NCBI Official Symbol:
TTC5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q8N0Z6
Protein GI Number:
67462006
Purification:
TTC5 Antibody is immunoaffinity purified IgG.
Research Area:
Signal Transduction
Swissprot #:
Q8N0Z6
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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