TLR2 Antibody
| Code | Size | Price |
|---|
| PSI-3135-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-3135-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TLR2 Antibody: TIL4, CD282, TIL4, Toll-like receptor 2
Application Note:
TLR2 antibody can be used for detection of TLR2 by Western blot at 1 μg/mL. Despite its predicted molecular weight, TLR2 runs at ~100 kDa in SDS-PAGE. This polyclonal antibody can also detect TLR2 by immunohistochemistry at 2 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TLR2 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-κB. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer can recognize a variety of bacterial and mycoplasma lipoproteins respectively.
Background References:
- Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
- Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
- Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
- O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.
Buffer:
TLR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TLR2 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human TLR2.
The immunogen is located within the first 50 amino acids of TLR2.
The immunogen is located within the first 50 amino acids of TLR2.
NCBI Gene ID #:
7097
NCBI Official Name:
toll-like receptor 2
NCBI Official Symbol:
TLR2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
O60603
Protein GI Number:
20140434
Purification:
TLR2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
O60603
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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