Avian Influenza Neuraminidase Antibody

Product Code: PSI-3423

Supplier: ProSci

Code	Size	Price

PSI-3423-0.02mg

0.02mg

£150.00

Quantity:

PSI-3423-0.1mg

0.1mg

£449.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit

Antibody Isotype: IgG

Antibody Clonality: Polyclonal

Regulatory Status: RUO

Application: Enzyme-Linked Immunosorbent Assay (ELISA)

Documents

Further Information

Additional Names:

Avian Influenza Neuraminidase Antibody: Neuraminidase

Application Note:

Avian influenza neuraminidase antibody can be used for the detection of the avian influenza neuraminidase protein from the H5N1 strain of Avian influenza A in ELISA. It will detect 10 ng of free peptide at 1 μg/mL.

Background:

Avian Influenza Neuraminidase Antibody: Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. Although it has been known that cleavage site and glycosylation patterns of the HA protein play important roles in determining the pathogenicity of H5 avian influenza viruses, it has only recently been shown that an additional glycosylation site within the globular head of the NA protein also contributes to the high virulence of the H5N1 virus.

Background References:

Thompson WW, Shay DK, Weintraub, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003; 289:179-86.
Alexander DJ. A review of avian influenza. Proceedings of the European Society for Veterinary Virology (ESVV) Symposium on Influenza Viruses of Wild and Domestic Animals. Vet. Microbiol. 2000; 74:3-13.
Shortridge KF, Zhou NN, Guan Y, et al. Characterization of avian H5N1 influenza viruses from poultry in Hong Kong. Virol. 1998; 252:331-42.
Buxton Bridges C, Katz JM, Seto WH, et al. Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong. J. Inf. Dis. 2000; 181:344-8.

Buffer:

Avian Influenza Neuraminidase Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration:

1 mg/mL

Conjugate:

Unconjugated

DISCLAIMER:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Immunogen:

Avian influenza neuraminidase antibody was raised against a synthetic peptide corresponding to 15 amino acids near the carboxy terminus of the avian influenza neuraminidase protein.

Efforts were made to use relatively conserved regions as the antigen.

The immunogen is located within the last 50 amino acids of Avian Influenza Neuraminidase.

NCBI Official Name:

Neuraminidase

NCBI Official Symbol:

NCBI Organism:

Influenza A virus (A/chicken/Scotland/1959(H5N1))

Physical State:

Liquid

Protein Accession #:

CAC95053

Protein GI Number:

39840718

Purification:

Avian Influenza Neuraminidase Antibody is affinity chromatography purified via peptide column.

Research Area:

Infectious Disease

Swissprot #:

Q710U6

User NOte:

Optimal dilutions for each application to be determined by the researcher.

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Avian Influenza Neuriminidase Peptide	PSI-3423P	ProSci	Summary Details