West Nile Virus Envelope Antibody
| Code | Size | Price |
|---|
| PSI-3439-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-3439-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Documents
Further Information
Additional Names:
West Nile Virus Envelope Antibody: Genome polyprotein, Core protein, NS1
Application Note:
West Nile virus envelope antibody can be used for the detection of the West Nile virus envelope protein in ELISA. It will detect 10 ng of free peptide at 1 μg/mL.
Background:
West Nile Virus Envelope Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. While the viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway, the highly glycosylated envelope protein plays a major role for WNV entry into target cells as this entry can be inhibited by using a recombinant domain III from the envelope glycoprotein. The WNV receptor has recently been identified as alpha v beta 3 integrin.
Background References:
- Gould LH and Fikrig E. West Nile virus: a growing concern.J. Clin. Invest. 2004; 113:1102-7.
- Yang JS, Ramanathan MP, Muthumani K, et al. Induction of inflammation by West Nile Virus capsid through the caspase-9 apoptotic pathway. Emerg. Infect. Dis. 2002; 8:1379-84.
- Chu JJ, Rajamanonmani R, Li J, et al. Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein. J. Gen. Virol. 2005; 86:405-12.
- Chu JJ and Ng ML. Interaction of West Nile virus with α v β 3 integrin mediates virus entry into cells. J. Biol. Chem. 2004; 279:54533-41.
Buffer:
West Nile Virus Envelope Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
West Nile Virus envelope antibody was raised against a synthetic peptide corresponding to 16 amino acids at the N terminus of the West Nile virus envelope protein.
The immunogen is located within amino acids 350 - 400 of West Nile Virus Envelope.
The immunogen is located within amino acids 350 - 400 of West Nile Virus Envelope.
NCBI Gene ID #:
912267
NCBI Official Name:
Envelope protein
NCBI Official Symbol:
WNVgp1
NCBI Organism:
West Nile virus
Physical State:
Liquid
Protein Accession #:
NP_776014
Protein GI Number:
27735302
Purification:
West Nile Virus Envelope Antibody is affinity chromatography purified via peptide column.
Research Area:
Infectious Disease
Swissprot #:
P06935
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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