CTRP1 Antibody

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ProSci
Product Code: PSI-3555
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-3555-0.02mg0.02mg£150.00
Quantity:
PSI-3555-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)

Images

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Western blot analysis of CTRP1 in MDA-MD-361 cell lysate with CTRP1 (IN) antibody at (A) 1 and (B) 2 μg/mL.
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Western blot analysis of CTRP1 in MDA-MD-361 cell lysate with CTRP1 (IN) antibody at (A) 1 and (B) 2 μg/mL.

Documents

Further Information

Additional Names:
CTRP1 Antibody: GIP, CTRP1, ZSIG37, UNQ310/PRO353, Complement C1q tumor necrosis factor-related protein 1, G protein-coupled receptor-interacting protein, GIP
Application Note:
CTRP1 antibody can be used for the detection of CTRP1 by Western blot at 1 and 2 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
CTRP1 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are seen at substantially higher levels in adipose tissues compared to those of normal mice.
Background References:
  • Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005; 115:911-9.
  • Tsao T-S, Lodish HF, and Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Euro. J. Pharmacol. 2002; 440:213-21.
  • Wong GW, Wang J, Hug C, et al. A family of Acrp30/ adiponectin structural and functional paralogs. Proc. Natl. Acad. Sci. USA 2004; 101:10302-7.
  • Shapiro L and Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. 1998; 8:335-8.
Buffer:
CTRP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%), Chicken: (79%)
Immunogen:
CTRP1 (IN) antibody was raised against a 16 amino acid synthetic peptide from near the center of human CTRP1.

The immunogen is located within amino acids 80 - 130 of CTRP1.
NCBI Gene ID #:
114897
NCBI Official Name:
C1q and tumor necrosis factor related protein 1
NCBI Official Symbol:
C1QTNF1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_940995
Protein GI Number:
38372917
Purification:
CTRP1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
These proteins are often highly modified post-translationally and migrate in SDS-PAGE at positions other than their predicted size.
Swissprot #:
Q9BXJ1
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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