ProSci

TLR1 Antibody

Product Code:
 
PSI-3639
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 3
Western blot analysis of TLR1 in mouse spleen lysate with TLR1 antibody at (A) 1, (B) 2, and (C) 4 μg/mL.
2 / 3
Immunohistochemistry of TLR1 in mouse spleen tissue with TLR1 antibody at 10 μg/mL.
3 / 3
Immunofluorescence of TLR1 in Mouse Spleen tissue
❮❯

Western blot analysis of TLR1 in mouse spleen lysate with TLR1 antibody at (A) 1, (B) 2, and (C) 4 μg/mL.
Immunohistochemistry of TLR1 in mouse spleen tissue with TLR1 antibody at 10 μg/mL.
Immunofluorescence of TLR1 in Mouse Spleen tissue

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CodeSizePrice
PSI-3639-0.02mg0.02mg£150.00
Quantity:
PSI-3639-0.1mg0.1mg£449.00
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Further Information

Additional Names:
TLR1 Antibody: TIL, CD281, rsc786, TIL. LPRS5, KIAA0012, Toll-like receptor 1, TIL
Application Note:
TLR1 antibody can be used for detection of TLR1 by Western blot at 1 to 4 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
TLR1 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR1 is co-expressed with TLR2 on myeloid cells of the innate immune systems in lymphoid tissue such as monocytes and dendritic cells where they form heterodimers that can recognize triacylated lipoproteins.
Background References:
  • Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
  • Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
  • Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
  • O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.
Buffer:
TLR1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TLR1 antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human TLR1.

The immunogen is located within amino acids 160 - 210 of TLR1.
NCBI Gene ID #:
7096
NCBI Official Name:
toll-like receptor 1
NCBI Official Symbol:
TLR1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 86 kDa

Observed: 90 kDa
Protein Accession #:
CAG38593
Protein GI Number:
49065550
Purification:
TLR1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
Q15399
User NOte:
Optimal dilutions for each application to be determined by the researcher.