ProSci

TLR6 Antibody

Product Code:
 
PSI-3651
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 2
Western blot analysis of TLR6 in Daudi cell lysate with TLR6 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
2 / 2
Immunocytochemistry of TLR6 in Jurkat cells with TLR6 antibody at 10 μg/mL.
❮❯

Western blot analysis of TLR6 in Daudi cell lysate with TLR6 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry of TLR6 in Jurkat cells with TLR6 antibody at 10 μg/mL.

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CodeSizePrice
PSI-3651-0.02mg0.02mg£150.00
Quantity:
PSI-3651-0.1mg0.1mg£449.00
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Further Information

Additional Names:
TLR6 Antibody: CD286, Toll-like receptor 6
Application Note:
TLR6 antibody can be used for detection of TLR6 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
Background:
TLR6 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses.
Background References:
  • Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
  • Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
  • McGettrick AF and O'Neill LAJ. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Imm. 2004; 41:577-82.
  • Takeuchi O, Kawai T, Sanjo H, et al. TLR6: A novel member of an expanding Toll-like receptor family. Gene 1999; 231:59-65.
Buffer:
TLR6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TLR6 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR6.

The immunogen is located within amino acids 160 - 210 of TLR6.
NCBI Gene ID #:
10333
NCBI Official Name:
toll-like receptor 6
NCBI Official Symbol:
TLR6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 91 kDa
Protein Accession #:
NP_006059
Protein GI Number:
20143971
Purification:
TLR6 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
This TLR6 antibody is predicted to have no cross-reactivity to other members of the TLR protein family.
Swissprot #:
Q9Y2C9
User NOte:
Optimal dilutions for each application to be determined by the researcher.