NALP2 Antibody

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ProSci
Product Code: PSI-3027
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-3027-0.02mg0.02mg£150.00
Quantity:
PSI-3027-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)

Images

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Western blot analysis of NALP2 in PC-3 cell lysate with NALP2 antibody at (A) 1 and (B) 2 μg/mL.
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Western blot analysis of NALP2 in PC-3 cell lysate with NALP2 antibody at (A) 1 and (B) 2 μg/mL.

Documents

Further Information

Additional Names:
NALP2 Antibody: NBS1, PAN1, NALP2, PYPAF2, CLR19.9, NBS1, NACHT, LRR and PYD domains-containing protein 2, Nucleotide-binding site protein 1
Application Note:
NALP2 antibody can be used for detection of NALP2 by Western blot at 1 to 2 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
NALP2 Antibody: NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1β-processing activity and is thought to function as a modulator of NF-κB and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.
Background References:
  • Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol. 2003; 4:95-104.
  • Bruey JM, Bruey-Sedano N, Newman R, et al. PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-κB and caspase-1 activation in macrophages. J. Biol. Chem. 2004; 279:51897-907.
  • Agostini L, Martinon F, Burns K, et al. NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004; 20:319-25.
  • Martinon F and Tschopp J. NLRs join TLRs as innate sensors of pathogens. TRENDS Imm. 2005; 26:447-54.
Buffer:
NALP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
NALP2 antibody was raised against a peptide corresponding to 12 amino acids near the carboxy terminus of human NALP2.

The immunogen is located within the last 50 amino acids of NALP2.
NCBI Gene ID #:
55655
NCBI Official Name:
NLR family, pyrin domain containing 2
NCBI Official Symbol:
NLRP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_060322
Protein GI Number:
8923473
Purification:
NALP2 Antibody is immunoaffinity chromatography purified IgG.
Research Area:
Apoptosis,Innate Immunity
Swissprot #:
Q9NX02
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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