IL-31 Antibody

Contact us
ProSci
Product Code: PSI-3745
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-3745-0.02mg0.02mg£150.00
Quantity:
PSI-3745-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

1 / 2
Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 μg/mL.
2 / 2
Immunohistochemistry of IL-31 in rat skeletal muscle tissue with IL-31 antibody at 10 μg/mL.
❮❯

Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 μg/mL.
Immunohistochemistry of IL-31 in rat skeletal muscle tissue with IL-31 antibody at 10 μg/mL.

Documents

Further Information

Additional Names:
IL-31 Antibody: 1700013B14Rik, Interleukin-31, IL-31
Application Note:
IL-31 antibody can be used for the detection of IL-31 by Western blot at 2.5 - 10 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
Background:
IL-31 Antibody: Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
Background References:
  • Dillon SR, Sprecher C, Hammond A, et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat. Immunol. 2004; 5:752-60.
  • Dreuw A, Radtke S, Pflanz S, et al. Characterization of the signaling capacities of the novel gp130-like cytokine receptor. J. Biol. Chem. 2004; 279:36112-20.
  • Diveu C, Lak-Hal AH, Froger J, et al. Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling. Eur. Cytokine Netw. 2004; 15:291-302.
  • Bilsborough J, Leung DY, Maurer M, et al. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. J. Allergy Clin. Immunol. 2006; 117:418-25.
Buffer:
IL-31 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IL-31 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of mouse IL-31.

The immunogen is located within amino acids 30 - 80 of IL-31.
NCBI Gene ID #:
76399
NCBI Official Name:
interleukin 31
NCBI Official Symbol:
Il31
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
AAS82846
Protein GI Number:
46241139
Purification:
IL-31 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction,Chemokines & Cytokines
Swissprot #:
Q6EAL8
User NOte:
Optimal dilutions for each application to be determined by the researcher.

Related Products

Product NameProduct CodeSupplier 
IL-31 PeptidePSI-3745PProSci Summary Details