SOCS1 Antibody
| Code | Size | Price |
|---|
| PSI-3767-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-3767-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SOCS1 Antibody: JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1, Suppressor of cytokine signaling 1, JAK-binding protein
Application Note:
SOCS1 antibody can be used for the detection of SOCS1 by Western blot at 1 - 4 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
SOCS1 Antibody: The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
Background References:
- Rakesh K and Agrawal DK. Controlling cytokine signaling by constitutive inhibitors. Biochem. Pharm. 2005; 70:649-57.
- O'Shea JJ, Gadina M, and Schreiber RD. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 2002; 109:S121-31.
- Kile BT, Schulman BA, Alexander WS, et al. The SOCS box: a tale of destruction and degradation. Trends Biochem. Sci. 2002; 27:235-41.
- Mansell A, Smith R, Doyle SL, et al. Suppressor of cytokine signaling 1 negatively mediates Toll-like receptor signaling by mediating Mal degradation. Nat. Immunol. 2006; 7:148-55.
Buffer:
SOCS1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SOCS1 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human SOCS1.
The immunogen is located within the first 50 amino acids of SOCS1.
The immunogen is located within the first 50 amino acids of SOCS1.
NCBI Gene ID #:
8651
NCBI Official Name:
suppressor of cytokine signaling 1
NCBI Official Symbol:
SOCS1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
CAB92528
Protein GI Number:
8217331
Purification:
SOCS1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction,Chemokines & Cytokines,Cancer
Swissprot #:
O15524
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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