TRPC6 Antibody
| Code | Size | Price |
|---|
| PSI-3899-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-3899-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TRPC6 Antibody: TRP6, FSGS2, TRP6, Short transient receptor potential channel 6, Transient receptor protein 6, TrpC6
Application Note:
TRPC6 antibody can be used for the detection of TRPC6 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for Immunohistochemistry starting at 10 μg/mL and Immunocytochemistry starting at 2 μg/mL . For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TRPC6 Antibody: The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, TRPC6 acts as a non-selective store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.
Background References:
- Contell C, Birnbaumer V, Flockerzi V, et al. A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 2002; 9:229-31.
- Dietrich A, Kalwa H, Rost BR, et al. The diacylglycerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch. 2005; 451:72-80.
- Trebak M, Vazquez G, Bird GSJ, et al. The TRPC3/6/7 subfamily of cation channels. Cell Calcium 2003; 33:451-61
Buffer:
TRPC6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TRPC6 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human TRPC6.
The immunogen is located within amino acids 50 - 100 of TRPC6.
The immunogen is located within amino acids 50 - 100 of TRPC6.
NCBI Gene ID #:
7225
NCBI Official Name:
transient receptor potential cation channel, subfamily C, member 6
NCBI Official Symbol:
TRPC6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAH93658
Protein GI Number:
62739910
Purification:
TRPC6 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction,Neuroscience
SPECIFICITY:
This antibody may cross-react with TRPC3.
Swissprot #:
Q9Y210
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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