Avian Influenza Nonstructural Protein 2 Antibody

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ProSci
Product Code: PSI-3917
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-3917-0.02mg0.02mg£150.00
Quantity:
PSI-3917-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)

Documents

Further Information

Additional Names:
Avian Influenza Nonstructural Protein 2 Antibody:
Application Note:
Avian Influenza Nonstructural Protein 2 antibody can be used for the detection of the Avian Influenza Nonstructural Protein 2 protein from influenza A in ELISA.
Background:
Avian Influenza Nonstructural Protein 2 Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however, it is in birds that all subtypes, including the so-called "avian flu" or H5N1, can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. One of the less studied proteins encoded by the influenza virus is the nonstructural protein (NS) 2. NS2 binds to the influenza matrix protein M1 that is bound to the ribonucleoprotein (RNP) complex and mediates the contact between the M1/RNP complex and the cellular exportin CRM, but does not interact with nucleosomes.
Background References:
  • Thompson WW, Shay DK, Weintraub, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003; 289:179-186.
  • Alexander DJ. A review of avian influenza. Proceedings of the European Society for Veterinary Virology (ESVV) Symposium on Influenza Viruses of Wild and Domestic Animals. Vet. Microbiol. 2000; 74:3-13.
  • Neumann G, Hughes MT and Kawaoka Y. Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1. EMBO J. 2000; 19:6751-8.
  • Garcia-Robles I, Akarsu H, Muller CW, et al. Interaction of influenza virus proteins with nucleosomes. Virology 2005; 332:329-36.
Buffer:
Avian Influenza Nonstructural Protein 2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Avian Influenza Nonstructural Protein 2 antibody was raised against a synthetic peptide corresponding to 14 amino acids near the middle of the Avian Influenza Nonstructural Protein 2 protein.

Efforts were made to use relatively conserved regions of the viral sequence as the antigen.

The immunogen is located within amino acids 40 - 90 of Avian Influenza Nonstructural Protein 2.
NCBI Official Name:
nonstructural protein 2
NCBI Organism:
Influenza A virus (A/Thailand/676/2005(H5N1))
Physical State:
Liquid
Protein Accession #:
ABC72654
Protein GI Number:
85680916
Purification:
Avian Influenza Nonstructural Protein 2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Infectious Disease
Swissprot #:
Q2L6Z2
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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