Cyclin O Antibody
| Code | Size | Price |
|---|
| PSI-3859-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-3859-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Cyclin O Antibody: CCNU, UDG2, Cyclin-O
Application Note:
Cyclin O antibody can be used for the detection of Cyclin O by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
Cyclin O Antibody: Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to instrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Supression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later publication identified this gene's product as a cyclin protein family member.
Background References:
- Roig MB, Roset R, Ortet L, et al. Identification of a novel cyclin required for the intrinsic apoptosis pathway in lymphoid cells. Cell Death Diff. 2009; 16:230-43.
- Muller SJ and Caradonna S. Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase. Biochim. Biophys. Acta 1991; 1088:197-207.
- Muller SJ and Caradonna S. Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase. J. Biol. Chem. 1993; 268:1310-9
Buffer:
Cyclin O Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Cyclin O antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human Cyclin O.
The immunogen is located within the first 50 amino acids of Cyclin O.
The immunogen is located within the first 50 amino acids of Cyclin O.
NCBI Gene ID #:
10309
NCBI Official Name:
Cyclin O
NCBI Official Symbol:
CCNO
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
39 kDa
Protein Accession #:
NP_066970
Protein GI Number:
153791755
Purification:
Cyclin O Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
SPECIFICITY:
At least two isoforms of Cyclin O are known to exist; this antibody will recognize both isoforms.
Swissprot #:
P22674
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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