IRF7 Antibody
| Code | Size | Price |
|---|
| PSI-3941-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-3941-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
IRF7 Antibody: IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H, Interferon regulatory factor 7, IRF-7
Application Note:
IRF7 antibody can be used for detection of IRF7 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human and mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human and mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
IRF7 Antibody: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
Background References:
- Malmgaard. J. Interferon & Cyto. Res. 2004; 24:439-54.
- Sato et al. Immunity 2000; 13:539-48.
- Fitzgerald et al. J. Exp. Med. 2003; 198:1043-55.
- Honda et al. Proc. Natl. Acad. Sci. USA 2004; 101:15416-21.
Buffer:
IRF7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IRF7 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human IRF7.
The immunogen is located within amino acids 420 - 470 of IRF7.
The immunogen is located within amino acids 420 - 470 of IRF7.
NCBI Gene ID #:
3665
NCBI Official Name:
interferon regulatory factor 7
NCBI Official Symbol:
IRF7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q92985
Protein GI Number:
116242593
Purification:
IRF7 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity,Cancer
Swissprot #:
Q92985
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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