LFG Antibody

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ProSci
Product Code: PSI-2285
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-2285-0.02mg0.02mg£150.00
Quantity:
PSI-2285-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of FAIM2 in EL4 cell lysate with FAIM2 antibody at (A) 0.5 and (B) 1 μg/mL.
2 / 2
Immunohistochemistry of FAIM2 in mouse brain tissue with FAIM2 antibody at 5 μg/mL.
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Western blot analysis of FAIM2 in EL4 cell lysate with FAIM2 antibody at (A) 0.5 and (B) 1 μg/mL.
Immunohistochemistry of FAIM2 in mouse brain tissue with FAIM2 antibody at 5 μg/mL.

Documents

Further Information

Additional Names:
FAIM2 Antibody: LFG, LFG2, NGP35, NMP35, TMBIM2, KIAA0950, LFG, Protein lifeguard 2, Fas apoptotic inhibitory molecule 2
Application Note:
FAIM2 antibody can be used for detection of FAIM2 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Background:
FAIM2 Antibody: Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. FAIM2 is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, FAIM2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. FAIM2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. FAIM2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. FAIM2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.
Background References:
  • Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
  • Somia NV, Schmitt MJ, Vetter DE, et al. FAIM2: an anti-apoptotic gene that provides protection from Fas-mediated cell death. Proc. Natl. Acad. Sci. USA 1999; 96:12667-72.
  • Schneider TJ, Fischer GM, Donohoe TJ, et al. A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. J. Exp. Med. 1999; 189:949-55.
  • Schweitzer B, Taylor V, Welcher AA, et al. Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system. Mol. Cell. Neurosci. 1998; 11:260-73.
Buffer:
FAIM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (94%)
Immunogen:
FAIM2 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human FAIM2.

The immunogen is located within the first 50 amino acids of FAIM2.
NCBI Gene ID #:
23017
NCBI Official Name:
Fas apoptotic inhibitory molecule 2
NCBI Official Symbol:
FAIM2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAF06327
Protein GI Number:
6273281
Purification:
FAIM2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
Swissprot #:
Q9BWQ8
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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