FAIM Antibody
| Code | Size | Price |
|---|
| PSI-2309-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-2309-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
FAIM Antibody: FAIM1, FAIM1, Fas apoptotic inhibitory molecule 1
Application Note:
FAIM antibody can be used for detection of FAIM by Western blot at 5 - 10 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
FAIM Antibody: The susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-κB and the Ras-ERK pathway.
Background References:
- Rothstein TL. Inducible resistance to Fas-mediated apoptosis in B cells. Cell Res. 2000; 10:245-66.
- Schneider TJ, Fischer GM, Donohoe TJ, et al. A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. J. Exp. Med. 1999; 189:949-55.
- Sole C, Dolcet X, Segura MF, et al. The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kappa B signaling. J. Cell Biol. 2004; 167:479-92.
Buffer:
FAIM Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Rat: (93%)
Immunogen:
FAIM antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human FAIM.
The immunogen is located within the last 50 amino acids of FAIM.
The immunogen is located within the last 50 amino acids of FAIM.
NCBI Gene ID #:
55179
NCBI Official Name:
Fas apoptotic inhibitory molecule
NCBI Official Symbol:
FAIM
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_060617
Protein GI Number:
8922536
Purification:
FAIM Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
Swissprot #:
Q9NVQ4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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