DRAM Antibody
PSI-4033
Rabbit
IgG
Polyclonal
RUO
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
No additional charges, what you see is what you pay! *
Code | Size | Price |
---|
PSI-4033-0.02mg | 0.02mg | £150.00 |
PSI-4033-0.1mg | 0.1mg | £449.00 |
* Rare exceptions are clearly labelled (only 0.14% of items!).
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Further Information
Antibody validated: Western Blot in human, mouse and rat samples, Immunofluorescence and Immunohistochemistry in human samples. All other applications and species not yet tested.
- Crighton, et al. Cell 2006; 126:121-34.
- Gozuacik and Kimchi. Oncogene. 2004; 23:2891-906.
- Crighton, et al. Autophagy 2007; 3:72-4.
The immunogen is located within amino acids 170-220 of DRAM.
Observed: 14 kD, 26kD
Independent Antibody Validation in Cell lines (Figure 2) shows similar DRAM expression profile in human, mouse and rat cell lines detected by two independent anti-DRAM antibodies that recognize different epitopes, 4033 against C-terminus domain and 4035 against N-terminus domain. DRAM proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies.
Induced Expression Validation (Figure 5): DRAM expression detected by anit-DRAM antibodies (4033) was up-regulated by CQ treatment in WT neural precursor cells.
Regulated expression validation (Figure 6): DRAM expression detected by anit-DRAM antibodies (4033) was down-regulated by in WT neural precursor cells.
Documents
References
- Walls et al. Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem. 2010;285(14):10497-507. PMID: 20123985
- Mehta et al. Manganese superoxide dismutase deficiency exacerbates ischemic brain damage under hyperglycemic conditions by altering autophagy. Transl Stroke Res. 2011;2(1):42-50. PMID: 21720543
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