FEZ1 Antibody

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ProSci
Product Code: PSI-4265
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-4265-0.02mg0.02mg£150.00
Quantity:
PSI-4265-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)

Images

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Western blot analysis of SAPAP2 in Raji cell lysate with SAPAP2 antibody at (A) 0.5 and (B) 1 μg/mL.
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Western blot analysis of SAPAP2 in Raji cell lysate with SAPAP2 antibody at (A) 0.5 and (B) 1 μg/mL.

Documents

Further Information

Additional Names:
FEZ1 Antibody: Fasciculation and elongation protein zeta-1, Zygin I
Application Note:
FEZ1 antibody can be used for the detection of FEZ1 by Western blot at 0.5 - 1 μg/mL. Despite its predicted molecular weight, FEZ1 will often run at higher molecular weight in SDS-PAGE.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
FEZ1 Antibody: Similar to its C. elegans homolog UNC-76, mammalian FEZ1, an abundant membrane protein and protein kinase C (PKC)-Z substrate, is involved in axonal guidance. Following phosphorylation by PKC-Z, FEZ1 translocates from the plasma membrane to the cytoplasm. FEZ1 is then able to interact with a number of proteins involved in axonal outgrowth and cellular transport such as DISC1, a candidate gene for schizophrenia, as well as kinesin-1, a microtubule-based motor protein. FEZ1 also interacts with proteins involved in transcriptional regulation and chromatin remodeling, suggesting that FEZ1 may have nuclear regulatory functions in addition to those for neuronal development. At least two distinct isoforms of FEZ1 are known to exist.
Background References:
  • Kuroda S, Nakagawa N, Tokunaga C, et al. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C z-interacting protein. J. Cell Biol.1999; 144:403-11.
  • Bloom L and Horvitz HR. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. Proc. Natl. Acad. Sci. USA1997; 88:9578-82.
  • Miyohi K, Honda A, Baba K, et al. Disrupted-in-schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol. Psychiatry2003; 8:685-94.
  • Blasius TL, Cai D, Jih GT, et al. Two binding partners cooperate to activate the molecular motor kinesin-1. J. Cell Biol.2007; 176:11-7.
Buffer:
FEZ1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
FEZ1 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FEZ1.

The immunogen is located within amino acids 270 - 320 of FEZ1.
NCBI Gene ID #:
9638
NCBI Official Name:
fasciculation and elongation protein zeta 1 (zygin I)
NCBI Official Symbol:
FEZ1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 42 kDa

Observed: 46 kDa
Protein Accession #:
Q99689
Protein GI Number:
13431526
Purification:
FEZ1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
Swissprot #:
Q99689
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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