MORF4 Antibody

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ProSci
Product Code: PSI-4275
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-4275-0.02mg0.02mg£150.00
Quantity:
PSI-4275-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of MORF4 in K562 cell lysate with MORF4 antibody at (A) 1 and (B) 2 μg/mL.
2 / 3
Immunohistochemistry of MORF4 in human brain tissue with MORF4 antibody at 5 μg/mL.
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Immunofluorescence of MORF4 in HepG2 cells with MORF4 antibody at 20 μg/mL.
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Western blot analysis of MORF4 in K562 cell lysate with MORF4 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of MORF4 in human brain tissue with MORF4 antibody at 5 μg/mL.
Immunofluorescence of MORF4 in HepG2 cells with MORF4 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
MORF4 Antibody: CSR, SEN, CSRB, SEN1
Application Note:
MORF4 antibody can be used for the detection of MORF4 by Western blot at 1 and 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
MORF4 Antibody: Cellular senescence is the terminal non-dividing state that normal cells enter following completion of their proliferative potential. Fusions of immortal human cell lines with each other have led to their assignment to one of four complementation groups. Mortality factor 4 (MORF4) was identified as the lead member of a family of transcription factor-like proteins that reverses this immortal phenotype. Like other members in this family, MORF4 is localized to the nucleus and possesses transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif that might allow it to form transcriptionally active homo- or heterodimers. MORF4 has been shown to bind to the transcription corepressors mSin3A and TLE, suggesting that together, these complexes may play a role in transcriptional repression of genes that lead to cellular senescence.
Background References:
  • Pereira-Smith OM and Smith JR. Genetic analysis of indefinite division in human cells: identification of four complementation groups. Proc. Natl. Acad. Sci. USA1988; 85:6042-6.
  • Bertram MJ, Berube NG, Hang-Swanson X, et al. Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. Mol. Cell. Biol.1999; 1479-85.
  • Yochum GS and Ayer DE. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pfl1, mSin3A, and transducin-like enhancer of split. Mol. Cell. Biol.2002; 22:7868-76.
Buffer:
MORF4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MORF4 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human MORF4.

The immunogen is located within amino acids 20 - 70 of MORF4.
NCBI Gene ID #:
10934
NCBI Official Name:
Putative transcription factor-like protein MORF4
NCBI Official Symbol:
MORF4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAD29871
Protein GI Number:
14917016
Purification:
MORF4 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
Q9Y690
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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