STEAP2 Antibody

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ProSci
Product Code: PSI-4307
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-4307-0.02mg0.02mg£150.00
Quantity:
PSI-4307-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of STEAP2 in human prostate tissue lysate with STEAP2 antibody at 1 μg/mL.
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Immunohistochemistry of STEAP2 in human colon tissue with STEAP2 antibody at 2.5 μg/mL.
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Immunofluorescence of STEAP2 in Human Colon cells with STEAP2 antibody at 20 μg/mL.
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Western blot analysis of STEAP2 in human prostate tissue lysate with STEAP2 antibody at 1 μg/mL.
Immunohistochemistry of STEAP2 in human colon tissue with STEAP2 antibody at 2.5 μg/mL.
Immunofluorescence of STEAP2 in Human Colon cells with STEAP2 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
STEAP2 Antibody: STMP, IPCA1, PUMPCn, STAMP1, PCANAP1, UNQ6507/PRO23203, Metalloreductase STEAP2, Prostate cancer-associated protein 1
Application Note:
STEAP2 antibody can be used for detection of STEAP2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
STEAP2 Antibody: The six-transmembrane epithelial antigen of prostate 2 (STEAP2) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 3 and STEAP4), STEAP2 promotes both iron and copper reduction. STEAP2 expression in transfected cells also correlated with iron or copper uptake, suggesting that the STEAP family of proteins may function to stimulate iron and copper uptake. STEAP2 is widely expressed in many tissues in the plasma membrane, but is most highly expressed in prostate. At least three isoforms of STEAP2 are known to exist.
Background References:
  • Porkka KP, Helenius MA and Visakorpi T. Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate. Lab Invest.2002; 82:1573-82.
  • Ohgami RS, Campagna DR, McDonald A, et al. The Steap proteins are metalloreductases. Blood2006; 108:1388-94.
  • Ohgami RS, Campagna DR, Greer EL, et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat. Genet.2005; 37:1264-9.
Buffer:
STEAP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
STEAP2 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human STEAP2.

The immunogen is located within the last 50 amino acids of STEAP2.
NCBI Gene ID #:
261729
NCBI Official Name:
six transmembrane epithelial antigen of the prostate 2
NCBI Official Symbol:
STEAP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 54 kDa

Observed: 55 kDa
Protein Accession #:
Q8NFT2
Protein GI Number:
83286886
Purification:
STEAP2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
This STEAP2 antibody does not cross-react with other STEAP proteins.
Swissprot #:
Q8NFT2
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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