CDNF Antibody
| Code | Size | Price |
|---|
| PSI-4345-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4345-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CDNF Antibody: ARMETL1, ARMETL1, Cerebral dopamine neurotrophic factor, ARMET-like protein 1
Application Note:
CDNF antibody can be used for detection of CDNF by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CDNF Antibody: The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson's disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson's disease. At least two isoforms of CDNF are known to exist.
Background References:
- Lindholm P, Voutilainen MH, Lauren J, et al. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature2007; 448:73-7.
- Petrova P, Raibekas A, Pevsner J, et al. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. J. Mol. Neurosci.2003; 20:173-88.
Buffer:
CDNF Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CDNF antibody was raised against a 12 amino acid synthetic peptide from near the amino terminus of human CDNF.
The immunogen is located within the first 50 amino acids of CDNF.
The immunogen is located within the first 50 amino acids of CDNF.
NCBI Gene ID #:
441549
NCBI Official Name:
cerebral dopamine neurotrophic factor
NCBI Official Symbol:
CDNF
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q49AH0
Protein GI Number:
143955278
Purification:
CDNF Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
This antibody does not cross-react with MANF.
Swissprot #:
Q49AH0
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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