LGP2 Antibody
| Code | Size | Price |
|---|
| PSI-4355-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4355-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
LGP2 Antibody: LGP2, RLR-3, D11LGP2, D11lgp2e, D11LGP2E, LGP2, Probable ATP-dependent RNA helicase DHX58, Probable ATP-dependent helicase LGP2
Application Note:
LGP2 antibody can be used for detection of LGP2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
LGP2 Antibody: Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
Background References:
- Akira S, Uematsu S, and Takeuchi O. Pathogen recognition and innate immunity. Cell2006; 124:783-801.
- Iwasaki A and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat. Immunol.2004; 5:987-95.
- Yoneyama M, Kikuchi K, Matsumoto K, et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol.2004; 5:730-7.
- Andrejeva J, Childs KS, Young DF, et al. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibits its activation of the IFN-betta promoter. Proc. Natl. Acad. Sci. USA, 2004; 101:17264-9.
Buffer:
LGP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
LGP2 antibody was raised against a 11 amino acid synthetic peptide from near the center of human LGP2.
The immunogen is located within amino acids 200 - 250 of LGP2.
The immunogen is located within amino acids 200 - 250 of LGP2.
NCBI Gene ID #:
79132
NCBI Official Name:
DEXH (Asp-Glu-X-His) box polypeptide 58
NCBI Official Symbol:
DHX58
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
EAW60798
Protein GI Number:
119581202
Purification:
LGP2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
Q96C10
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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