TEM2 Antibody
| Code | Size | Price |
|---|
| PSI-4363-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4363-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TEM2 Antibody: Rhes, TEM2, MGC:4834, GTP-binding protein Rhes, Ras homolog enriched in striatum
Application Note:
TEM2 antibody can be used for detection of TEM2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TEM2 Antibody: Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.
Background References:
- Vargiu P, Morte B, Manzano J, et al. Thyroid hormone regulation of rhes, a novel RAS homolog gene expressed in the striatum. Brain Res. Mol. Brain Res.2001; 94:1-8.
- Spano D, Branchi I, Rosica A, et al. Rhes is involved in striatal function. Mol. Cell. Biol.2004; 24:5788-96.
- Carson-Walter EB, Watkins DN, Nanda A, et al. Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res.2001; 61:6649-55.
- Yamamoto Y, Irie K, Nanda A, et al. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. Oncogene2004; 23:3889-97.
Buffer:
TEM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TEM2 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of the human TEM2.
The immunogen is located within amino acids 20 - 70 of TEM2.
The immunogen is located within amino acids 20 - 70 of TEM2.
NCBI Gene ID #:
23551
NCBI Official Name:
RASD family, member 2
NCBI Official Symbol:
RASD2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q96D21
Protein GI Number:
21362868
Purification:
TEM2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
TEM2 antibody may cross-react with the closely related protein RASD1.
Swissprot #:
Q96D21
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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