Grik2 Antibody
| Code | Size | Price |
|---|
| PSI-4387-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4387-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Grik2 Antibody: EAA4, GLR6, MRT6, GLUK6, GLUR6, GluK2, Glutamate receptor ionotropic, kainate 2, Excitatory amino acid receptor 4
Application Note:
Grik2 antibody can be used for detection of Grik2 by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
Grik2 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik2, also known as glutamate receptor 6, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Recent reports have suggested that defects in the Grik2 protein may be associated with autosomal recessive mental retardation and possibly other neurological disorders such as schizophrenia. Numerous isoforms of Grik2 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow. This Grik2 antibody may exhibit some cross-reactivity to Grik3.
Background References:
- Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.
- Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.
- Paschen W, Blackstone CD, Huganir RL, et al. Human GluR6 kainate receptor (GRIK2): molecular cloning, expression, polymorphism, and chromosomal assignment. Genomics1994; 20:435-40.
- Motazacker MM, Rost BR, Hucho T, et al. A defect in the ionotrophic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation. Am. J. Hum. Genet.2007; 81:792-8.
Buffer:
Grik2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Grik2 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human Grik2.
The immunogen is located within the last 50 amino acids of Grik2.
The immunogen is located within the last 50 amino acids of Grik2.
NCBI Gene ID #:
2898
NCBI Official Name:
glutamate receptor, ionotropic, kainate 2
NCBI Official Symbol:
GRIK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q13002
Protein GI Number:
2492627
Purification:
Grik2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
Swissprot #:
Q13002
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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