Grik3 Antibody
| Code | Size | Price |
|---|
| PSI-4389-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4389-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Grik3 Antibody: EAA5, GLR7, GLUR7, GluK3, GluR7a, Glutamate receptor ionotropic, kainate 3, Excitatory amino acid receptor 5
Application Note:
Grik3 antibody can be used for detection of Grik3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
Grik3 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia. This Grik3 antibody does not cross-react with Grik2.
Background References:
- Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.
- Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.
- Puranam RS, Eubanks JH, Heinemann SF, et al. Chromosomal localization of gene for human glutamate receptor subunit-7. Somat. Cell Mol. Genet.1993; 19:581-8.
- Pinheiro PS, Perrais D, Coussen F, et al. GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses. Proc. Natl. Acad. Sci. USA2007; 104:12181-6.
Buffer:
Grik3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Grik3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of the human Grik3.
The immunogen is located within amino acids 30 - 80 of Grik3.
The immunogen is located within amino acids 30 - 80 of Grik3.
NCBI Gene ID #:
2899
NCBI Official Name:
glutamate receptor, ionotropic, kainate 3
NCBI Official Symbol:
GRIK3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
CAI19119
Protein GI Number:
56205347
Purification:
Grik3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
Swissprot #:
Q13003
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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