FEZ2 Antibody
Code | Size | Price |
---|
PSI-4403-0.02mg | 0.02mg | £150.00 |
Quantity:
PSI-4403-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Images
Documents
Further Information
Additional Names:
FEZ2 Antibody: HUM3CL, Fasciculation and elongation protein zeta-2, Zygin II
Application Note:
FEZ2 antibody can be used for the detection of FEZ2 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunoflourescence starting at 5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
FEZ2 Antibody: Fasciculation and elongation protein zeta-2 (FEZ2) is a homolog to the mammalian FEZ1, itself an ortholog of the C. elegans UNC-76. In contrast to FEZ1, FEZ2 mRNA is widely expressed in mouse tissues. FEZ2 interacts with protein kinase C (PKC)-zeta substrate and induces neurite extension of PC12 cells when co-expressed with a constitutively active form of PKC-zeta, suggesting FEZ2 may play an important role in the morphological changes of various cells by associating with PKC-zeta in a tissue non-specific manner. FEZ2 can interact with FEZ1 through its c-terminal regions and especially its coiled-coil region. At least two isoforms of FEZ2 are known to exist.
Background References:
- Fujita T, Ikuta J, Okajima T, et al. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Biochem. Biophys. Res. Commun.2004; 313:738-44.
- Kuroda S, Nakagawa N, Tokunaga C, et al. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C z-interacting protein. J. Cell Biol.1999; 144:403-11.
- Assmann EM, Alborghetti MR, Camargo MER, et al. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. J. Biol. Chem.2006; 281:9869-81.
Buffer:
FEZ2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
FEZ2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human FEZ2.
The immunogen is located within the last 50 amino acids of FEZ2.
The immunogen is located within the last 50 amino acids of FEZ2.
NCBI Gene ID #:
9637
NCBI Official Name:
fasciculation and elongation protein zeta 2 (zygin II)
NCBI Official Symbol:
FEZ2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001036013
Protein GI Number:
110349756
Purification:
FEZ2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
Swissprot #:
Q9UHY8
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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