Slitrk2 Antibody

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ProSci
Product Code: PSI-4457
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-4457-0.02mg0.02mg£150.00
Quantity:
PSI-4457-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of Slitrk2 in rat brain tissue lysate with Slitrk2 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of Slitrk2 in human brain tissue with Slitrk2 antibody at 2.5 μg/mL.
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Immunofluorescence of Slitrk2 in Human Brain cells with Slitrk2 antibody at 20 μg/mL.
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Western blot analysis of Slitrk2 in rat brain tissue lysate with Slitrk2 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of Slitrk2 in human brain tissue with Slitrk2 antibody at 2.5 μg/mL.
Immunofluorescence of Slitrk2 in Human Brain cells with Slitrk2 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
Slitrk2 Antibody: CXorf2, SLITL1, CXorf2, KIAA1854, UNQ9197/PRO34756, SLIT and NTRK-like protein 2
Application Note:
Slitrk2 antibody can be used for detection of Slitrk2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
Slitrk2 Antibody: SLIT and NTRK-like family 2 (Slitrk2) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk2 is expressed primarily in neurons in the ventricular layer of the brain. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk2 inhibited neurite outgrowth in cultured neurons. Deletion analysis indicated that the functional difference between Slitrk2 and Slitrk1 is within their intracellular domains. At least two isoforms of this protein are known to exist.
Background References:
  • Aruga J and Mikoshiba K. Identification and characterization of Slitrk, a novel transmembrane protein family controlling neurite outgrowth. Mol. Cell Neurosci.2003; 24:117-29.
  • Aruga J, Yokota N, and Mikoshiba K. Human SLITRK family genes: genomic organization and expression profiling in normal and brain tumor tissue. Gene2003; 315:87-94.
Buffer:
Slitrk2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Slitrk2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human Slitrk2.

The immunogen is located within amino acids 770 - 820 of Slitrk2.
NCBI Gene ID #:
84631
NCBI Official Name:
SLIT and NTRK-like family, member 2
NCBI Official Symbol:
SLITRK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q9H156
Protein GI Number:
46397026
Purification:
Slitrk2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
Swissprot #:
Q9H156
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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