Rim3 Antibody
| Code | Size | Price |
|---|
| PSI-4471-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4471-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Rim3 Antibody: NIM3, RIM3, KIAA0237, Regulating synaptic membrane exocytosis protein 3, RIM3 gamma, Nim3
Application Note:
Rim3 antibody can be used for detection of Rim3 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
Rim3 Antibody: Rab3-interacting molecules (RIMs) are synaptic proteins are synaptic proteins necessary for neural transmission and plasticity. While both Rim1 and Rim 2 are thought to be effector proteins for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner, less is known of Rim3. Expression of Rim3 in PC12 cells induced a significant increase in calcium-triggered exocytosis, with no appreciable change in the baseline release, suggesting that it plays a role in the regulation of exocytosis. Rim3 protein localizes primarily to neuronal dendrites and the postsynaptic densities, as opposed to Rim1 which is found in presynapse locations, indicating that Rim3 may contribute to synapse transmission and plasticity.
Background References:
- Wang Y, Sugita S, and Sudhof TC. The RIM/NIM family of neuronal C2 domain proteins: interactions with Rab3 and a new class of Src homology 3 domain proteins. J. Biol. Chem.2000; 275:20033-44.
- Liang F, Zhang B, Tang J, et al. RIM3gamma is a postsynaptic protein in the rat central nervous system. J. Comp. Neurol.2007; 503:501-10.
Buffer:
Rim3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%)
Immunogen:
Rim3 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human Rim3.
The immunogen is located within amino acids 60 - 110 of Rim3.
The immunogen is located within amino acids 60 - 110 of Rim3.
NCBI Gene ID #:
9783
NCBI Official Name:
regulating synaptic membrane exocytosis 3
NCBI Official Symbol:
RIMS3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_055562
Protein GI Number:
48476344
Purification:
Rim3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
This antibody is predicted to have no cross-reactivity to other Rim proteins.
Swissprot #:
Q9UJD0
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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