LGI3 Antibody
| Code | Size | Price |
|---|
| PSI-4493-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4493-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
LGI3 Antibody: LGIL4, LGIL4, UNQ8190/PRO23199, Leucine-rich repeat LGI family member 3, LGI1-like protein 4
Application Note:
LGI3 antibody can be used for the detection of LGI3 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
LGI3 Antibody: The leucine-rich, glioma inactivated gene 3 (LGI3) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI3 have not been found to be associated with ADTLE. LGI3 expression is induced in rat astrocyte cultures by the amyloid beta (Abeta) peptide and accumulated on neuronal plasma membranes of aged monkey brains and co-localized with Abeta.
Background References:
- Gu W, Gibert Y, Wirth T, et al. Using gene-history and expression analysis to assess the involvement of LGI genes in human disorders. Mol. Biol. Evol.2005; 22:2209-16.
- Chernova OB, Somerville RP and Cowell JK. A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. Oncogene1998; 17:2873-81.
- Berkovic SF, Izzillo P, McMahon JM, et al. LGI1 mutations in temporal lobe epilepsies. Neurology2004; 62:1115-9.
- Kimura N, Ishii Y, Suzaki S, et al. Abeta upregulates and colocalizes with LGI3 in cultured rat astrocytes. Cell Mol. Neurobiol.2007; 27:335-50.
Buffer:
LGI3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
LGI3 antibody was raised against a 12 amino acid synthetic peptide from near the center of human LGI3.
The immunogen is located within amino acids 390 - 440 of LGI3.
The immunogen is located within amino acids 390 - 440 of LGI3.
NCBI Gene ID #:
203190
NCBI Official Name:
leucine-rich repeat LGI family, member 3
NCBI Official Symbol:
LGI3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAQ88483
Protein GI Number:
37181338
Purification:
LGI3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
Two isoforms of LGI3 are known to exist; this LGI3 antibody will recognize both. This LGI3 antibody is predicted to be specific to LGI3 and not recognize other LGI proteins. The observed higher molecular weight band may represent a post-translationally modified form of LGI3.
Swissprot #:
Q8N145
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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