EVER1 Antibody

Contact us
ProSci
Product Code: PSI-4547
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-4547-0.02mg0.02mg£150.00
Quantity:
PSI-4547-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

1 / 2
Western blot analysis of EVER1 in A-20 cell lysate with EVER1 antibody at (A) 1 and (B) 2 μg/mL.
2 / 2
Immunohistochemistry of EVER1 in human spleen with EVER1 antibody at 2.5 μg/mL.
❮❯

Western blot analysis of EVER1 in A-20 cell lysate with EVER1 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of EVER1 in human spleen with EVER1 antibody at 2.5 μg/mL.

Documents

Further Information

Additional Names:
EVER1 Antibody: EV1, EVER1, EVIN1, LAK-4P, Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1
Application Note:
EVER1 antibody can be used for the detection of EVER1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
EVER1 Antibody: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance.
Background References:
  • Majewski S, Jablonska J and Orth G. Epidermodysplasia verruciformis. Immunological and nonimmunological surveillance mechanisms: role in tumor progression. Clin. Dermatol.1997; 15:321-34.
  • Ramoz N, Rueda L-A, Bouadjar B, et al. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Nat. Genetics2002; 32:579-81.
  • Keresztes G, Mutai H and Heller S. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. BMC Genomics2003; 4:24-34.
  • Lazarczyk L, Pons C, Mendoza JA, et al. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. J. Exp. Med.2008; 205:35-42.
Buffer:
EVER1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
EVER1 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human EVER1.

The immunogen is located within the first 50 amino acids of EVER1.
NCBI Gene ID #:
11322
NCBI Official Name:
transmembrane channel-like 6
NCBI Official Symbol:
TMC6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAM44452
Protein GI Number:
25527208
Purification:
EVER1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.
Swissprot #:
Q7Z403
User NOte:
Optimal dilutions for each application to be determined by the researcher.

Related Products

Product NameProduct CodeSupplier 
EVER1 PeptidePSI-4547PProSci Summary Details