Cathelicidin Antibody
| Code | Size | Price |
|---|
| PSI-4429-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4429-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Cathelicidin Antibody: LL37, CAP18, CRAMP, HSD26, CAP-18, FALL39, FALL-39, Cathelicidin antimicrobial peptide, 18 kDa cationic antimicrobial protein
Application Note:
Cathelicidin antibody can be used for detection of Cathelicidin by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
Cathelicidin Antibody: One component of host defense at mucosal surfaces is epithelial-derived antimicrobial peptides. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Finally, Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.
Background References:
- Zaiou M and Gallo RL. Cathelicidins, essential gene-encoded mammalian antibiotics. J. Mol. Med. 2002; 80:549-61.
- Agerberth B, Gunne H, Odeberg J, et al. FALL-39, a Putative Human Peptide Antibiotic, is Cysteine-Free and Expressed in Bone Marrow and Testis. Proc. Natl. Acad. Sci. USA 1995; 92:195-9.
- Nizet V, Ohtake T, Lauthe X, et al. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 2001; 414:454-7.
- Koczulla R, von Degenfeld G, Kupatt C, et al. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J. Clin. Invest. 2003; 111:1665-72.
Buffer:
Cathelicidin Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Cathelicidin antibody was raised against a 17 amino acid synthetic peptide near the center of the human Cathelicidin.
The immunogen is located within amino acids 50 - 100 of Cathelicidin.
The immunogen is located within amino acids 50 - 100 of Cathelicidin.
NCBI Gene ID #:
820
NCBI Official Name:
cathelicidin antimicrobial peptide
NCBI Official Symbol:
CAMP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 19 kDa
Observed: 18 kDa
Observed: 18 kDa
Protein Accession #:
NP_004336
Protein GI Number:
39753970
Purification:
Cathelicidin Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
P49913
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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