LGI4 Antibody

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ProSci
Product Code: PSI-4513
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-4513-0.02mg0.02mg£150.00
Quantity:
PSI-4513-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)

Images

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Western blot analysis of LGI4 in human brain tissue lysate with LGI4 antibody at (A) 1 and (B) 2 μg/mL.
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Western blot analysis of LGI4 in human brain tissue lysate with LGI4 antibody at (A) 1 and (B) 2 μg/mL.

Documents

Further Information

Additional Names:
LGI4 Antibody: LGIL3, LGIL3, UNQ6515/PRO21485, Leucine-rich repeat LGI family member 4, LGI1-like protein 3
Application Note:
LGI4 antibody can be used for the detection of LGI4 by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
LGI4 Antibody: The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.
Background References:
  • Gu W, Gibert Y, Wirth T, et al. Using gene-history and expression analysis to assess the involvement of LGI genes in human disorders. Mol. Biol. Evol.2005; 22:2209-16.
  • Chernova OB, Somerville RP and Cowell JK. A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. Oncogene1998; 17:2873-81.
  • Berkovic SF, Izzillo P, McMahon JM, et al. LGI1 mutations in temporal lobe epilepsies. Neurology2004; 62:1115-9.
  • Gu W, Sander T, Becker T, et al. Genotypic association of exonic LGI4 polymorphism and childhood absence epilepsy. Neurogenetics2004; 5:41-4.
Buffer:
LGI4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
LGI4 antibody was raised against a 14 amino acid synthetic peptide from near the center of human LGI4.

The immunogen is located within amino acids 240 - 290 of LGI4.
NCBI Gene ID #:
163175
NCBI Official Name:
leucine-rich repeat LGI family, member 4
NCBI Official Symbol:
LGI4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAM49552
Protein GI Number:
21359654
Purification:
LGI4 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
Two isoforms of LGI4 are known to exist; this LGI4 antibody will recognize only the larger form. This LGI4 antibody is predicted to be specific to LGI4 and not recognize other LGI proteins.
Swissprot #:
Q8N135
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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