Nanos2 Antibody
| Code | Size | Price |
|---|
| PSI-4645-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4645-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Nanos2 Antibody: NOS2, NOS2, Nanos homolog 2, NOS-2
Application Note:
Nanos2 antibody can be used for detection of Nanos2 by Western blot at 2 to 4 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
Nanos2 Antibody: Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3-null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3-null background. Nanos3 expression can not rescue Nanos2-null defects.
Background References:
- Lehmann R and Nusslein-Volhard C. The maternal gene nanos has a central role in posterior pattern formation of the drosophila embryo. Development1991; 112:679-91.
- Tsuda M, Sasaoka Y, Kiso M, et al. Conserved role of nanos proteins in germ cell development. Science2003; 301:1239-41.
- Sato K, Hayashi Y, Ninomiya Y, et al. Maternal Nanos represses hid/skl-dependent apoptosis to maintain the germ line in Drosophila embryos. Proc. Natl. Acad. Sci. USA2007; 104:7455-60.
- Haraguchi S, Tsuda M, Kitajima S, et al. Nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development. Mech. Dev.2003; 120:721-31.
Buffer:
Nanos2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Nanos2 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human Nanos2.
The immunogen is located within the last 50 amino acids of Nanos2.
The immunogen is located within the last 50 amino acids of Nanos2.
NCBI Gene ID #:
339345
NCBI Official Name:
nanos homolog 2 (Drosophila)
NCBI Official Symbol:
NANOS2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
P60321
Protein GI Number:
41688561
Purification:
Nanos2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
This Nanos2 antibody will not cross-react with either Nanos 1 or Nanos3.
Swissprot #:
P60321
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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