Slc22A17 Antibody
| Code | Size | Price |
|---|
| PSI-4651-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4651-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Slc22A17 Antibody: BOCT, BOIT, 24p3R, NGALR, hBOIT, NGALR2, NGALR3, BOCT, Solute carrier family 22 member 17, 24p3 receptor
Application Note:
Slc22A17 antibody can be used for detection of Slc22A17 by Western blot at 0.5 μg/mL. Antibody can also be used for immunoflourescence starting at 20 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested.
Background:
Slc22A17 Antibody: The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.
Background References:
- Koepsell H and Endou H. The SLC22 drug transporter family. Pflugers Arch. 2004; 447:666-76.
- Rizwan AN and Burckhardt G. Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm. Res. 2007; 24:450-70.
- Miharada K, Hiroyama T, Sudo K, et. al. Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells. J. Cell Physiol. 2008; 215:526-37.
- Devireddy LR, Gazin C, Zhu X, et al. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 2005; 123:1293-305.
Buffer:
Slc22A17 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (86%)
Immunogen:
Slc22A17 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human Slc22A17.
The immunogen is located within the last 50 amino acids of Slc22A17.
The immunogen is located within the last 50 amino acids of Slc22A17.
NCBI Gene ID #:
51310
NCBI Official Name:
solute carrier family 22, member 17
NCBI Official Symbol:
SLC22A17
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 59 kDa
Observed: 61 kDa
Observed: 61 kDa
Protein Accession #:
Q8WUG5
Protein GI Number:
27805426
Purification:
Slc22A17 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
Q8WUG5
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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