CLIP170 Antibody

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ProSci
Product Code: PSI-4659
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-4659-0.02mg0.02mg£150.00
Quantity:
PSI-4659-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)

Images

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Western blot analysis of CLIP170 in rat brain tissue lysate with CLIP170 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunofuorescence of CLIP170 in human brain tissue with CLIP170 antibody at 20 μg/mL.
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Western blot analysis of CLIP170 in rat brain tissue lysate with CLIP170 antibody at (A) 0.5 and (B) 1 μg/mL.
Immunofuorescence of CLIP170 in human brain tissue with CLIP170 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
CLIP170 Antibody: RSN, CLIP, CYLN1, CLIP170, CLIP-170, RSN, CAP-Gly domain-containing linker protein 1, Cytoplasmic linker protein 1
Application Note:
CLIP170 antibody can be used for detection of CLIP170 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunoflourescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CLIP170 Antibody: CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
Background References:
  • Bilbe G, Delabie J, Bruggen J, et al. Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease. EMBO J.1992; 11:2103-13.
  • Diamantopoulos GS, Perez F, Goodson HV, et al. Dynamic localization of CLIP-170 to microtubule plus ends is coupled to microtubule assembly. J. Cell Biol.1999; 144:99-112.
  • Pierre P, Scheel J, Richard JE, et al. CLIP-170 links endocytic vesicles to microtubules. Cell70:887-900.
  • Suzuki K and Takahashi K. Regulation of lamellipodia formation and cell invasion by CLIP-170 in invasive human breast cancer cells. Biochem. Biophys. Res. Commun.2008; 368:199-204.
Buffer:
CLIP170 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CLIP170 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human CLIP170.

The immunogen is located within amino acids 1340 - 1390 of CLIP170.
NCBI Gene ID #:
6249
NCBI Official Name:
CAP-GLY domain containing linker protein 1
NCBI Official Symbol:
CLIP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_002947
Protein GI Number:
4506751
Purification:
CLIP170 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
P30622
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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