TNPO3 Antibody
| Code | Size | Price |
|---|
| PSI-4599-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4599-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TNPO3 Antibody: IPO12, TRNSR, LGMD1F, MTR10A, TRN-SR, TRN-SR2, IPO12, Transportin-3, Importin-12, Imp12
Application Note:
TNPO3 antibody can be used for detection of TNPO3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human and rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human and rat samples. All other applications and species not yet tested.
Background:
TNPO3 Antibody: TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.
Background References:
- Kataoka N, Bachorik JL and Dreyfuss G. Transportin-SR, a nuclear import receptor for SR proteins. J. Cell Biol.1999; 145:1145-52.
- Lai M-C, Lin R-I, Huang S-Y, et al. A human importin-b family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins. J. Biol. Chem.2000; 275:7950-7.
- Brass AL, Dykxhoorn DM, Benita Y, et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science2008; 319:921-6.
Buffer:
TNPO3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TNPO3 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human TNPO3.
The immunogen is located within amino acids 220 - 270 of TNPO3.
The immunogen is located within amino acids 220 - 270 of TNPO3.
NCBI Gene ID #:
23534
NCBI Official Name:
transportin 3
NCBI Official Symbol:
TNPO3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 95, 101 kDa
Observed: 96 kDa?
Observed: 96 kDa?
Protein Accession #:
EAW83708
Protein GI Number:
119604114
Purification:
TNPO3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
Q9Y5L0
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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