BICD2 Antibody

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ProSci
Product Code: PSI-4677
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-4677-0.02mg0.02mg£150.00
Quantity:
PSI-4677-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)

Images

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Western blot analysis of BICD2 in 293 cell lysate with BICD2 antibody at (A) 1 and (B) 2 μg/mL.
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Western blot analysis of BICD2 in 293 cell lysate with BICD2 antibody at (A) 1 and (B) 2 μg/mL.

Documents

Further Information

Additional Names:
BICD2 Antibody: SMALED2, bA526D8.1, KIAA0699, Protein bicaudal D homolog 2, Bic-D 2
Application Note:
BICD2 antibody can be used for detection of BICD2 by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
BICD2 Antibody: BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.
Background References:
  • Holland PM, Milne A, Garka K, et al. Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2. J. Biol. Chem.2002; 277:16229-40.
  • Hoogenraad CC, Akhmanova A, Howell SA, et al. Mammalian golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. EMBO J.2001; 4041-54.
  • Teuling E, van Dis V, Wulf PS, et al. A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice. Hum. Mol. Genet.2008; 17:2849-62.
Buffer:
BICD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
BICD2 antibody was raised against a 14 amino acid synthetic peptide from near the center of human BICD2.

The immunogen is located within amino acids 300 - 350 of BICD2.
NCBI Gene ID #:
23299
NCBI Official Name:
bicaudal D homolog 2 (Drosophila)
NCBI Official Symbol:
BICD2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 94 kDa

Observed: 100 kDa
Protein Accession #:
CAI41013
Protein GI Number:
57208854
Purification:
BICD2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
This BICD2 antibody will not cross-react with BICD1.
Swissprot #:
Q8TD16
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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