Stella Antibody
| Code | Size | Price |
|---|
| PSI-4755-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4755-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Stella Antibody: STELLA, STELLAR, Developmental pluripotency-associated protein 3, Stella-related protein
Application Note:
Stella antibody can be used for detection of Stella by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
Stella Antibody: Stella was initially identified in primordial germ cells and pre-implantation embryos whose expression as a maternal factor is important in early embryonic development but is not required for germ cell specification in mice. In humans, Stella is thought to be a marker for pluripotency in embryonic stem (ES) cells as its expression is observed in primordial germ cells of both sexes and germ cell tumors but not in normal somatic tissues. However, in ES cell colonies, heterogeneous expression of Stella was seen in high throughput in situ hybridization assays, indicating that higher levels of complexity exist in otherwise thought to be undifferentiated ES cells. At least two distinct isoforms of Stella are known to exist.
Background References:
- Sato M, Kimura T, Kurokawa K, et al. Identification of PGC7, a new gene expressed specifically in preimplatation embryos and germ cells. Mech. Dev.2002; 113:91-4.
- Bortvin A, Goodheart M, Liao M, et al. Dppa3/Pgc7/stella is a maternal factor and is not required for germ cell specification in mice. BMC Dev. Biol.2004; 4:2.
- Bowles J, Teasdale RP, James K, et al. Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. Cytogenet. Genome Res.2003; 101:261-5.
- Carter MG, Stagg CA, Falco G, et al. An in situ hybridization-based screen for heterogeneously expressed genes in mouse ES cells. Gene Expr. Patterns2008; 8:181-8.
Buffer:
Stella Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Stella antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human Stella.
The immunogen is located within the last 50 amino acids of Stella.
The immunogen is located within the last 50 amino acids of Stella.
NCBI Gene ID #:
359787
NCBI Official Name:
developmental pluripotency associated 3
NCBI Official Symbol:
DPPA3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_954980
Protein GI Number:
40548326
Purification:
Stella Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
Q6W0C5
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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