KINDLIN3 Antibody

Contact us
ProSci
Product Code: PSI-4797
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-4797-0.02mg0.02mg£150.00
Quantity:
PSI-4797-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)

Images

1 / 1
Western blot analysis of KINDLIN3 in rat spleen lysate with KINDLIN3 antibody at (A) 1 and (B) 2 μg/mL.
❮❯

Western blot analysis of KINDLIN3 in rat spleen lysate with KINDLIN3 antibody at (A) 1 and (B) 2 μg/mL.

Documents

Further Information

Additional Names:
KINDLIN3 Antibody: URP2, KIND3, MIG-2, MIG2B, URP2SF, UNC112C, URP2, Fermitin family homolog 3, Kindlin-3
Application Note:
KINDLIN3 antibody can be used for detection of KINDLIN3 by Western blot at 1 and 2 μg/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
KINDLIN3 Antibody: The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.
Background References:
  • Ussar S, Wang HV, Linder S, et al. The Kindlins: subcellular localization and expression during murine development. Exp. Cell Res.2006; 312:3142-51.
  • Weinstein EJ, Bourner M, Head R, et al. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. Biochim. Biophys. Acta2003; 1637:207-16.
  • Boyd RS, Adam PJ, Patel S, et al. Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B. Leukemia2003; 17:1605-12.
  • Mory A, Feigelson SW, Yarali N, et al. Kindlin-3: a new gene involved in the pathogenesis of LAD-III. Blood2008; 112:2591.
Buffer:
KINDLIN3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
KINDLIN3 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of the human KINDLIN3.

The immunogen is located within the last 50 amino acids of KINDLIN3.
NCBI Gene ID #:
83706
NCBI Official Name:
fermitin family homolog 3 (Drosophila)
NCBI Official Symbol:
FERMT3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 73 kDa

Observed: 73 kDa
Protein Accession #:
NP_848537
Protein GI Number:
41281905
Purification:
KINDLIN3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
Q86UX7
User NOte:
Optimal dilutions for each application to be determined by the researcher.

Related Products

Product NameProduct CodeSupplier 
KINDLIN3 PeptidePSI-4797PProSci Summary Details