Akirin2 Antibody
| Code | Size | Price |
|---|
| PSI-4805-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4805-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Akirin2 Antibody: FBI1, C6orf166, dJ486L4.2, Akirin-2
Application Note:
Akirin2 antibody can be used for detection of Akirin2 by Western blot at 0.5 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
Akirin2 Antibody: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α and IL-1β signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Background References:
- Goto A, Matsushita K, Gesellchen V, et al. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat. Immunol.2008; 9:97-104.
- Beutler B and Moresco EM. Akirins versus infection. Nat. Immunol.2008; 9:7-9.
- Sutterwala FS and Flavell RA. Immunology: cascade into clarity. Nature2008; 451:254-5.
- Tanji T and Ip YT. Regulators of the Toll and Imd pathways in the Drosophila innate immune response. Trends Immunol.2005; 26:193-8.
Buffer:
Akirin2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
Akirin2 antibody was raised against a 15 amino acid synthetic peptide near the center of the human Akirin2.
The immunogen is located within amino acids 80 - 130 of Akirin2.
The immunogen is located within amino acids 80 - 130 of Akirin2.
NCBI Gene ID #:
55122
NCBI Official Name:
akirin 2
NCBI Official Symbol:
AKIRIN2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
EAW48578
Protein GI Number:
119568963
Purification:
Akirin2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
Q53H80
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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