Rkhd2 Antibody

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ProSci
Product Code: PSI-4857
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-4857-0.02mg0.02mg£150.00
Quantity:
PSI-4857-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)

Images

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Western blot analysis of Rkhd2 in rat heart tissue lysate with Rkhd2 antibody at (A) 0.5 μg/mL and (B) 1 μg/mL.
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Western blot analysis of Rkhd2 in rat heart tissue lysate with Rkhd2 antibody at (A) 0.5 μg/mL and (B) 1 μg/mL.

Documents

Further Information

Additional Names:
Rkhd2 Antibody: RKHD2, BM-013, MEX-3C, RNF194, RKHD2, RNA-binding E3 ubiquitin-protein ligase MEX3C, RING finger and KH domain-containing protein 2
Application Note:
Rkhd2 antibody can be used for detection of Rkhd2 by Western blot at 0.5 - 1 μg/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
Rkhd2 Antibody: Rkhd2, also known as MEX3C is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd2, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. It has been suggested that genetic variations in Rkhd2 may be associated with susceptibility to essential hypertension type 8. Rkhd3 and Rkhd4, but not Rkhd2, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
Background References:
  • Draper BW, Mello CC, Bowerman B, et al. MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegansembryos. Cell1996; 87:205-16.
  • Liu J, Valencia-Sanchez MA, Hannon GJ, et al. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat. Cell Biol2005; 7:719-23.
  • Guzman B, Cormand B, Ribases M, et al. Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene. Hypertension2006; 48:883-91.
  • Buchet-Poyau K, Courchet J, Le Hir H, et al. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Nucleic Acids Res.2007; 35:1289-300.
Buffer:
Rkhd2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rkhd2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human RKHD2.

The immunogen is located within amino acids 540 - 590 of Rkhd2.
NCBI Gene ID #:
51320
NCBI Official Name:
mex-3 homolog C (C. elegans)
NCBI Official Symbol:
MEX3C
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_057710
Protein GI Number:
148229134
Purification:
Rkhd2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
Swissprot #:
Q5U5Q3
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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