Disp2 Antibody
| Code | Size | Price |
|---|
| PSI-4883-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4883-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Disp2 Antibody: DISPB, HsT16908, DISPB, KIAA1742, Protein dispatched homolog 2
Application Note:
Disp2 antibody can be used for the detection of Disp2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
Disp2 Antibody: Disp2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the Disp proteins have been implicated in these pathways. Recently, it has been shown that Disp2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased Disp2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by Disp2 mutants. At least two isoforms of Disp2 are known to exist. This Disp2 antibody is predicted to not cross-react with Disp1 or Disp3.
Background References:
- Katoh Y and Katoh M. Identification and characterization of DISP3 gene in silico. Int. J. Oncol.2005; 26:551-6.
- Katoh Y and Katoh M. Hedgehog signaling pathway and gastric cancer. Can. Biol. & Ther.2005; 4:1050-4.
- Li N, Flynt AS, Kim HR, et al. Dispatched homolog 2 is targeted by miR-214 through a combination of three week microRNA recognition sites. Nuc. Acids Res.2008; 36:4277-85.
Buffer:
Disp2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Disp2 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human Disp2.
The immunogen is located within amino acids 1210 - 1260 of Disp2.
The immunogen is located within amino acids 1210 - 1260 of Disp2.
NCBI Gene ID #:
85455
NCBI Official Name:
dispatched homolog 2 (Drosophila)
NCBI Official Symbol:
DISP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
A7MBM2
Protein GI Number:
160380692
Purification:
Disp2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
A7MBM2
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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