MettL7A Antibody
| Code | Size | Price |
|---|
| PSI-4889-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4889-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
MettL7A Antibody: AAM-B, Methyltransferase-like protein 7A, Protein AAM-B
Application Note:
MettL7A antibody can be used for detection of MettL7A by Western blot at 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 2 μg/mL. For immunofluorescence start at 2 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
Background:
MettL7A Antibody: MettL7A belongs to the methyltransferase superfamily. It is a probable methyltransferase. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Often methylation occurs on nucleic bases in DNA or amino acids in protein structures. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. DNA methylation may be necessary for normal growth from embryonic stages in mammals. When mutant embryonic stem cells lacking the murine DNA methyltransferase gene were introduced to a germline of mice they caused a recessive lethal phenotype. Methylation may also be linked to cancer development as methylation of tumor suppressor genes promotes tumorgenesis and metastasis.
Background References:
- Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res.2003; 13:2265-70.
- Li E, Bestor TH, and Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell1992; 69:915-26.
- Laird PW and Jaenisch R. DNA Methylation and Cancer. Human Molecular Genetics1994; 3:1487-95.
Buffer:
MettL7A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MettL7A antibody was raised against a 13 amino acid synthetic peptide near the center of human MettL7A.
The immunogen is located within amino acids 130 - 180 of MettL7A.
The immunogen is located within amino acids 130 - 180 of MettL7A.
NCBI Gene ID #:
25840
NCBI Official Name:
methyltransferase like 7A
NCBI Official Symbol:
METTL7A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_054752
Protein GI Number:
89145417
Purification:
MettL7A Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
At least two isoforms of MettL7A are known to exist. This antibody is predicted to not cross-react with MettL7B.
Swissprot #:
Q9H8H3
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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